工作单位：

国家儿童医学中心 首都医科大学附属北京儿童医院

导师层次与类别：

硕导/学术

最高学历：

博士研究生

最高学位与授予单位：

博士、中国疾病预防控制中心

Email：

chenxp1111@163.com

研究方向：

儿童肠道病毒、呼吸道合胞病毒分子流行病学及感染致病机制研究

代表性教学、科研项目或研究成果（论文、专利专著、教材、成果获奖）：

科研项目：

1.国家自然科学基金面上项目，82172245，《基于人FcRn转基因小鼠对埃可病毒11型感染引起新生儿脓毒症免疫机制研究》，2022/01-2025/12，71.5万元，在研，主持。

2.国家自然科学基金面上项目，81971922，《基于CRISPR-Cas9表面蛋白文库对埃可病毒18型受体的高通量筛选、鉴定及功能研究》，2020/01-2023/12，55万元，在研，主持。

3.国家科技重大专项，2018ZX10201002-003-009, 《手足口病相关临床危险因素分析》，2018/01-2020/12，24.51万元，已结题，主持。

4.北京自然基金青年项目，7184208，《基于CRISPR-Cas9系统对埃可病毒18感染相关宿主关键基因的筛选研究》，2018/01-2019/12，10万元，已结题，主持。

5.国家科技重大专项，2017ZX10104001-005-010, 《基于病毒全基因组序列溯源技术在医院系统的应用》，2017/01-2020/12，42.51万元，已结题，主持。

6.北京市市委组织部，北京市优秀人才基金项目，2014000021469G237，《我国部分地区儿童病毒性脑炎病原中肠道病毒的分子流行病学研究》，2015.01-2016.12，5万元，已结题，主持。

部分论文：

1. Xin Zhao#, Guigen Zhang#, Sheng Liu#, Xiangpeng Chen#, Ruchao Peng, Lianpan Dai, Xiao Qu, Shihua Li, Hao Song, Zhengrong Gao, Pengfei Yuan, Zhiheng Liu, Changyao Li, Zifang Shang, Yan Li,  Meifan Zhang, Jianxun Qi, Han Wang, Ning Du, Yan Wu, Yuhai Bi, Shan Gao, Yi Shi, Jinghua Yan, Yong Zhang, Zhengde Xie*, Wensheng Wei*, George F. Gao*. Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Cell. 2019 May 30;177(6):1553-1565.e16. doi: 10.1016/j.cell.2019.04.035. Epub 2019 May 16.  IF 38.639

2.  Qi Li #,  Xiangpeng Chen #, Junhong Ai, Lei Li, Changchong Li, Yun Zhu, Ran Wang, Yali Duan, Meng Zhang, Zhengde Xie. Clinical and molecular epidemiologic features of enterovirus D68 infection in children with acute lower respiratory tract infection in China. Arch Virol. 2023 Jul 15;168(8):206. doi: 10.1007/s00705-023-05823-5.

3.  Junhong Ai#, Yun Zhu, Yali Duan, Meng Zhang, Gen Lu, Yun Sun, Rong Jin, Yunxiao Shang, Changchong Li, Baoping Xu, Xiangpeng Chen*, Zhengde Xie*. A multicenter study on molecular epidemiology of rhinovirus isolated from children with community acquired pneumonia in China during 2017–2019. Infect Genet Evol. 2022 Nov 15;105384. doi: 10.1016/j.meegid.2022.105384.   IF 4.392

4. Qi Li#, Ran Wang#, Hui Xu, Linlin Zhang, Yiliang Fu, Jiao Tian, Mengjia Liu, Guoshuang Feng, Yueping Zeng, Xiangpeng Chen*, Zhengde Xie*. Epidemiology and Disease Burden of Hospitalized Children With Viral Central Nervous System Infections in China, 2016 to 2020. Pediatric Neurology. 2023 Jan; 138:38-44. Doi: 10.1016/j.pediatrneurol.2022.09.003. IF 4.21

5. Xiangpeng Chen#, Yun Zhu, Qi Li, Gen Lu, Changchong Li, Rong Jin, Lei Li, Baoping Xu, Liwei Gao, Ju Yin, Zhengde Xie*. Genetic characteristics of human coronavirus HKU1 in mainland China during 2018. Arch Virol. 2022 Nov;167(11):2173-2180. doi: 10.1007/s00705-022-05541-4.  IF 2.70

6. Meng Zhang#, Xiangpeng Chen#, Wei Wang, Qi Li, Zhengde Xie*. Genetic characteristics of Coxsackievirus A6 from children with hand, foot and mouth disease in Beijing, China, 2017-2019. Infect Genet Evol. 2022 Dec;106:105378. doi: 10.1016/j.meegid.2022.105378.  Epub 2022 Oct 17. IF 4.392

7. Xiangpeng Chen#, Xiao Qu#, Congcong Liu#, Yong Zhang, Guigen Zhang, Pu Han, Yali Duan, Qi Li, Liang Wang, Wenjing Ruan, Peiyi Wang, Wensheng Wei, GeorgeF. Gao*, Xin Zhao*,  Zhengde Xie*. Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18. mBio. 2022 Aug 30;13(4):e0116622. doi: 10.1128/mbio.01166-22. Epub 2022 Jul 5.  IF 7.786

8. Xiangpeng Chen#, Yun Zhu, Wei Wang, Changchong Li, Shuhua An, Gen Lu, Rong Jin, Baoping Xu, Yunlian Zhou, Aihuan Chen, Lei Li, Meng Zhang, Zhengde Xie*. A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019. Virol Sin. 2021 Dec;36(6):1475-1483. IF 6.947

9. Yali Duan#, Baoping Xu, Changchong Li, Yixiao Bao, Shuhua An, Yunlian Zhou, Aihuan Chen, Li Deng, Limin Ning, Yun Zhu, Wei Wang, Meng Zhang, Lili Xu, Xiangpeng Chen*, Zhengde Xie*. Molecular Characteristics of Human Adenovirus Type 3 Circulating in Parts of China during 2014–2018. Front Microbiol. 2021; 12: 688661. doi.org/10.3389/fmicb.2021.688661. IF 6.20

10. Yali Duan#, Changchong Li, Li Deng, Shuhua An, Yun Zhu, Wei Wang, Meng Zhang, Lili Xu, Baoping Xu, Xiangpeng Chen*, Zhengde Xie*. Genetic Analysis of Human Adenovirus Type 7 Strains Circulating in Different Parts of China. Virol Sin. 2021 Jun;36(3):382-392. doi: 10.1007/s12250-020-00334-y.  IF 6.947

11. Xiangpeng Chen#, Yong Zhang, Naiying Mao, Shuangli Zhu, Tianjiao Ji, Wenbo Xu*. Intranasal immunization with coxsackievirus A16 virus‑like particles confers protection against lethal infection in neonatal mice. Arch Virol. 2019 Dec;164(12):2975-2984. doi: 10.1007/s00705-019-04418-3. Epub 2019 Sep 30.   2.243

12. Xiangpeng Chen#, Zhengde Xie*. Concerning the discovery of mechanism for enterovirus B infection published in Cell. Pediatr Invest 2019 Sep; 3(3): 194-195. DOI:10.1002/ped4.12151.

13. Xiangpeng Chen#, Tianjiao Ji#, Jiayun Guo, Wei Wang, Wenbo Xu*, Zhengde Xie*. Molecular Epidemiology of Echovirus 18 Circulating in Mainland China from 2015 to 2016. Virol Sin. 2019 Feb;34(1):50-58. doi: 10.1007/s12250-018-0080-8. Epub 2019 Feb 21.    

14. Xiangpeng Chen#, Jiayun Guo, Jingjie Li,　Qiuping Li,　Junhong Ai,　Suzhen Sun*,　Zhengde Xie*. Serotypes of human enteroviruses causing pediatric viral encephalitis and meningitis in Hebei province, China, from 2013 to 2015. Pediatr Invest 2018,2(2): 98-104. DOI: 10.1002/ped4.12037.

15. Xiangpeng Chen#, Baoping Xu#, Jiayun Guo#, Changchong Li, Shuhua An, Yunlian Zhou, Aihuan Chen, Li Deng, Zhou Fu, Yun Zhu, Chunyan Liu, Lili Xu, Wei Wang, Kunling Shen*, Zhengde Xie*. Genetic variations in the fusion protein of respiratory syncytial virus isolated from children hospitalized with community-acquired pneumonia in China. Sci Rep. 2018 Mar14;8(1):4491.

16. Xiangpeng Chen#, Jingjie Li#, Jiayun Guo, Wenbo Xu, Suzhen Sun*, Zhengde Xie*. An outbreak of echovirus 18 encephalitis/meningitis in children in Hebei Province, China, 2015. Emerging Microbes & Infections. 2017 Jun 21;6(6):e54. doi: 10.1038/emi.2017.39. IF:5.605

社会兼职：

国家卫生健康委“健康儿童行动—儿童健康知识普及计划”公益项目专家委员会委员，中国初级卫生保健基金会病原检测专业委员会常务委员，中国医疗保健国际交流促进会分子诊断学分会委员，中国医药教育协会儿科专业委员会      委员，中国微生物学会病毒学专委会青年工作委员会委员， 中国中药协会儿童健康与药物研究专业委员会委员，中国中药协会儿童健康与药物研究专业委员会 感染学组秘书，中国医疗保健国际交流促进会分子诊断学分会委员，《中华实验和临床病毒学杂志》编委，《JPIDS儿科感染中文版》青年编委。