科研项目: 1.首都医科大学科研培育基金,PYZ22142,GBP5影响TCA代谢酶琥珀酰化修饰促进结核感染巨噬细胞代谢重塑和免疫应答研究,2023-01-01至2023-12-31,5万,主持 2.中科院病原微生物与免疫学重点实验室,面上项目,CASPMI202201,GBP5 促进结核感染巨噬细胞中 NLRP3 炎症小体活化的机制研究,2022-07-01至2024-07-31,在研,主持 3.国家自然科学基金委员会, 青年科学基金项目, 81701971, GBP5在抗结核感染中对巨噬细胞炎症小体调控的机制研究,2018-01-01 至 2020-12-31,结题,主持 4.中华人民共和国科学技术部, 艾滋病和病毒性肝炎等重大传染病防治科技部重大专项子任务, 2018ZX10101004002, 多种族儿童结核病生物样本库的建立与诊疗技术验证和示范推广, 2018-01 至 2021-06,结题,主持 5.北京市卫生健康委员会, 首都卫生发展科研专项青年优才项目, 2018-4-1142, 第三代头孢菌素在新生儿抗感染治疗中的群体药代动力学研究, 2018-01 至 2021-12, 结题,主持 6.国家外专局,出国培训项目, P182001033, GBP5基因对于结核分枝杆菌感染后巨噬细胞功能以及能量代谢的影响, 2018-11 至 2019-05,结题,主持 7. 国家自然科学基金委员会, 应急管理项目,81441067,基于药物基因组学的儿童抗结核药物致肝毒性DNA标记物的筛选及预测,2015-01-01至2015-12-31,结题,主持 8.中国博士后基金委员会,面上项目,188384,巨噬细胞凋亡相关基因多态性与结核病易感相关性研究,2013-07至2014-12,结题,主持 9.北京市人力资源和社会保障局,人才培养,2013ZZ,细胞因子、细胞因子受体以及相关信号通路分子基因多态性与中国儿童结核病易感的相关性研究,2013-05至2014-07结题,主持 代表性论文: (1) Xue Tian#, Lei Dong#, Ting-Ting Jiang#, Bo-Hao Tang, Ze-Ming Wang, Yue-E Wu, Dian-Ping You, Jing Bi, Su-Yun Qian*, Hui Qi*; Adong Shen* Meropenem for children with severe pneumonia: Protocol for a randomized controlled trial, Frontiers in Pharmacology, 2022;13:1021661. (2) Hui Qi; Yuee Wu; Yali Liu; Chen Kou; Zeming Wang; Xiaoxia Peng; Liang Chen; Hong Cui; Yajuan Wang; Jieqiong Li; Wei Zhao; Adong Shen*; Latamoxef for Neonates With Early-Onset Neonatal Sepsis: A Study Protocol for a Randomized Controlled Trial, Frontiers in Pharmacology, 2021, 12. (3) Xue Li#, Hui Qi#, Fei Jin#, Bufan Yao, Yuee Wu, YuJie Qi, Chen Kou, Xirong Wu, Xiaojing Luo, Yanhua Shen, Xu Zheng, Yonghong Wang, Fang Xu, Weiwei Jiao, Jieqiong Li, Jing Xiao, Yining Dong, Bin Du, Haiyan Shi, Baoping Xu, Adong Shen*, Wei Zhao*; Population Pharmacokinetics-Pharmacodynamics of Ceftazidime in Neonates and Young Infants: Dosing Optimization for Neonatal Sepsis, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2021,02: 105868. (4) Xu Fang; Qi Hui; Li Jieqiong; Sun Lin; Gong Juanjuan; Chen Yuanying; Shen Adong; Li Wei ; Mycobacterium tuberculosis infection up-regulates MFN2 expression to promote NLRP3 inflammasome f ormation, The Journal of Biological Chemistry, 2020, 295(51): 17684-17697. (5) Hui Qi#; Chen Kou#; YuJie Qi#; BoHao Tang; YueE Wu; Fei Jin; Xiaojing Luo; Yanhua Shen; Yajie Guo; Xue Qi; Yacui Wang; Qian Dong; Xingkai Chen; Haiyan Shi; Yi Zheng; Wei Zhao*; Adong Shen*; Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants, International Journal of Antimicrobial Agents. 2019, 53(3): 347-351. (6) Hui Qi#; Yongbiao Zhang#; Lin Sun#; Cheng Chen#; Biao Xu; Fang Xu; Jiawen Liu; Jincheng Liu; Chen Chen; Weiwei Jiao; Chen Shen; Jing Xiao; Jieqiong Li; Yajie Guo; Yonghong Wang; Qinjing Li; Qingqin Yin; Yingjia Li; Ting Wang; Xingyun Wang; Mingliang Gu; Jun Yu And Adong Shen*; Discovery of susceptibility loci associated with tuberculosis in Han Chinese, Human Molecular Genetics, 2017, 26(23): 4752-4763. 3. 获奖: (1) 结核病诊断新技术的建立及推广应用,北京医学科技奖二等奖,2022年,第五完成人; (2) 结核病关键诊疗技术的建立及推广应用,中华医学科技奖三等奖,2022年,第六完成人; (3) 结核病关键诊断技术的创新性建立及应用,北京市科学技术奖科学自然科学奖, 2022年,第七完成人。 |