代表性教学、科研项目或研究成果(论文、专利专著、教材、成果获奖): | 1、科研项目: (1)北京市卫生健康委员会高层次公共卫生技术人才培养计划,学科骨干,项目编号:2022-3-041,42万,执行年限2022.4-2025.4 (2)首都卫生发展科研专项项目自主创新项目,基于多交叉恒温扩增的儿童结核病分子诊断技术研发及临床验证,项目编号首发2020-2-1142,30万,执行年限2020.1-2022.12 (3)北京市优秀人才培养资助青年拔尖个人项目,项目编号2016000021223ZK38,50万,执行年限2016.9-2019.9 (4)国家自然科学基金应急管理项目,结核分枝杆菌rpoA/C突变在利福平耐药及菌株传播中的作用,项目编号81541062,12万,执行年限2016.1-2016.12 (5)北京市卫生系统高层次卫生技术人才培养计划,学科骨干,项目编号2015-3-081,21万,执行年限2015.12-2018.12 (6)首都卫生发展科研专项项目青年项目,儿童结核病病原体分子鉴定和耐药分子特征研究,项目编号首发2011-1007-01,8万,执行年限2012.8-2015.8 (7)北京市留学人员科技活动择优资助项目,儿童结核病感染菌株鉴定及耐药性研究,15万,执行年限2011-2012年 (8)国家自然科学基金青年项目,结核分枝杆菌embB基因突变的生物学效应研究,项目编号30901632,21万,执行年限2010.1-2012.12 (9)北京市科技新星计划(A类),依托面上项目:宿主基因多态性与结核分枝杆菌易感性的关系研究,项目编号2008A079,8万,执行年限2009.1-2011.12 2、代表性论文: (1) Zhdanova S*, Jiao WW*, Sinkov V, Khromova P, Solovieva N, Mushkin A, Mokrousov I, Belopolskaya O, Masharsky A, Vyazovaya A, Rychkova L, Kolesnikova L, Zhuravlev V, Shen AD, Ogarkov O. Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing. Int J Mol Sci, 2023, 24, 10302. (2) Jiang TT#, Sun L#, Wang TY, Qi H, Tang H, Wang YC, Han Q, Shi XQ, Bi J*, Jiao WW*, Shen AD*. The clinical significance of macrolide resistance in pediatric Mycoplasma pneumoniae infection during COVID-19 pandemic. Front Cell Infect Microbiol, 2023; 13: 1181402. (3) Liao Q#, Zheng Y#, Wang Y#, Ye L#, Liu X#, Jiao W#, Liu Y, Zhu Y, Jia J, Sun L*, Shen A*, Wan C*. Effectiveness of Bacillus Calmette-Guérin vaccination against severe childhood tuberculosis in China: a case-based, multicenter retrospective study. Int J Infect Dis. 2022, 121: 113-119. (4) Jiao WW#, Wang GR#, Sun L, Xiao J, Li JQ, Wang YC, Quan ST, Huang HR*, Shen AD*. Multiple Cross Displacement Amplification Combined With Real-Time Polymerase Chain Reaction Platform: A Rapid, Sensitive Method to Detect Mycobacterium tuberculosis. Front. Microbiol. 2021, 12: 812690. doi: 10.3389/fmicb.2021.812690. (5) Wang XY, Wang GR, Wang YC, Quan ST, Qi H, Sun L, Shen C, Huang HR, Jiao WW*, Shen AD*. Development and preliminary application of multiplex loop-mediated isothermal amplification coupled with lateral flow biosensor for detection of Mycobacterium tuberculosis complex. Front Cell Infect Microbiol. 2021, 11: 666492. (6) Jiao WW, Wang Y, Wang GR, Wang YC, Xiao J, Sun L, Li JQ, Wen SA, Zhang TT, Ma Q, Huang HR*, Shen AD*. Development and Clinical Validation of Multiple Cross Displacement Amplification Combined With Nanoparticles-Based Biosensor for Detection of Mycobacterium tuberculosis: Preliminary Results. Front. Microbiol. 2019, 10:2135. (7) Li QJ#, Jiao WW#, Yin QQ, Li YJ, Li JQ, Xu F, Sun L, Xiao J, Qi H, Wang T, Mokrousov I, Huang HR*, Shen AD*. Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains. Int J Antimicrob Agents. 2017, 49(6):757-762. (8) Li QJ#, Jiao WW#, Yin QQ, Xu F, Li JQ, Sun L, Xiao J, Li YJ, Mokrousov I, Huang HR*, Shen AD*. Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China. Antimicrob Agents Chemother. 2016, 60(5): 2807-2812. 3、成果获奖: (1)2021年度北京医学科技奖二等奖,《结核病诊断新技术的建立及推广应用》,第九完成人。 (2)2021年度首都医科大学自然科学技术奖三等奖,《呼吸道病原体分子诊断技术的研发及临床评估》,第二完成人。 (3)2022年度中华医学科学技术奖三等奖,《结核病关键诊疗技术的建立及推广应用》,第八完成人。 (4)2022年度北京市科技进步奖二等奖,《结核病关键诊断技术的创新性建立及应用》,第三完成人。 |