代表性教学、科研项目或研究成果(论文、专利专著、教材、成果获奖): | 1.近5年的科研课题 1) 国家“十四五”重点研发计划子课题,基于临床大数据的极/超早产儿救治-后遗症防治循证医学研究及质控体系建设,2022YFC2704805,336万元,2022/12-2025/11 2)首都卫生发展科研专项,危重新生儿脐静脉置管致门脉血栓危险因素及演变结局前瞻队列研究,首发2022-2-2095, 41.6万元,2022/1-2024/12 3)北京市自然科学基金面上项目,HMGB1-RAGE/PI3K致缺氧缺血性脑损伤新生大鼠小胶质M1/M2极化失衡的机制研究,7192061,20万元,2019/1-2022/12 4)北京市医院管理中心儿科协同创新课题,基于转运前危重儿评分及转运后诊疗结局的危重新生儿转运标准研究,XTCX201816,40万元,2019/1-2022/12 5)国家自然科学基金面上项目,HMGB1调节CPEB1-NR2A通路在新生儿缺氧缺血性脑损伤发病机制中的作用研究,81671505,57万元,2017/1-2020/12 2. 10篇代表性论著(第一作者或通信作者) 1) Sun Y, Zhu X, Zhu K, Yu J, Cheng L, Hei M*. High-mobility Group Box 1 contributes to Hypoxic-ischemic brain damage by facilitating imbalance of microglial polarization through RAGE-PI3K/Akt pathway in neonatal rats[J]. Int J Med Sci, 2022, 19(14): 2093-2103. Doi: 10.7150/ijms.78641 2) Qu W, Shen Y, Qi Y, Jiang M, Zheng X, Zhang J, Wu D, He W, Geng W, Hei M*. Comparison of four neonatal transport scoring methods in the prediction of mortality risk in full-term, out-born infants: A single-centre retrospective cohort study[J]. Eur J Pediatr, 2022 doi.org/10.1007/s00431-022-04506-8 3) Hei M, Li X, Shi Y, Cao Y, Sun J, Wu H, Jiang S, Ma X, Wang Y, Sun H, Zhang H, Du L, Zhou W, Lee SK, Chen C*, on behalf of the Chinese Neonatal Network (CHNN). The Chinese Neonatal Network: a national protocol for collaborative research and quality improvement in neonatal care[J]. BMJ Open 2022;12:e051175. doi:10.1136/bmjopen-2021-051175 4) Zhu K, Zhu X, Sun S, Yang W, Liu S, Tang Z, Zhang R, Shen T, Hei M*. Inhibition of TLR4 Prevents Hippocampal Hypoxic-ischemic Injury by Regulating Ferroptosis in Neonatal Rats[J]. Experiment Neurol. 2021; 345: 113828 doi: 10.1016 5) Zheng X, Geng W, Li G, Jin F, Liu H, Jia S, Hei M*. Retrieval of an intracardiac cannula fragment via femoral access in a premature infant. Neonatology, 2021 DOI 10.1159/000515464 6) M Hei*, X Gao, Y Li, X Gao, Z Li, S Xia, A Zhang, S Han, H Gao, S Nong, A Zhang, J Li, T Wang, XY Ye, SK Lee. Family integrated care for preterm infants in China: A cluster randomized controlled trail. J Pediatr, 2021, 228:36-43 7) Sun Y, Hei* M, Fang Z, Tang Z, Wang B, Hu N. High-mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia. Front Cell Neurosci. 2019; 13: 506 8) Tang Z, Cheng S, Sun Y, Zhang Y, Xiang X, Ouyang Z, Zhu X, Wang B, Hei M*. Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity. Experiment Neurol. 2019; 321: 11309-11322 9) Hei M, Yi Z*. Environmental factors for the development of fetal urinary malformations. World J Pediatrics, 2014;10 (1): 17-23 10) Hei M*, Luo Y, Zhang X, Liu F. Tanshinone IIa Alleviates the Biochemical Changes Associated with Hypoxic Ischemic Brain Damage in a Rat Model. Phytotherapy Research, 2011, 25(12): 1865-1869 3. 专利 1)黑明燕,耿文静,靳绯,姜敏,董世霄,向希盈. 用于脐静脉穿刺的扩张器. 实用新型专利,2020年4月21日,ZL2019 2 0799882.0 4. 参编教材 1)陈超,杜立中,封志纯主编. 新生儿学(第1版). 人民卫生出版社,2022年,北京 ISBN 978-7-117-29745-5 2)王天有,申昆玲,沈颖主编. 诸福棠实用儿科学(第9版). 人民卫生出版社,2022年,北京 ISBN 978-7-117-32904-0 5. 成果获奖 2021年度首都医科大学科学技术奖科技进步奖二等奖(排名第1),家庭参与式看护对危重新生儿的脑保护与机制,首都医科大学 |